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Dilated Cardiomyopathy

DCM in Dobermans

Has your Doberman been diagnosed with DCM? Help us find the cure.

Canine Lymphoma

Canine Lymphoma

Oncology
Investigational

Lymphoma is one of the most commonly encountered cancers in the dog. The incidence of canine lymphoma has steadily increased with approximately 84 per 10,000 dogs diagnosed each year. This randomized, double-masked, placebo-controlled, GCP pivotal field study is evaluating the effectiveness and safety of verdinexor for the treatment of naïve or first relapse stages II, III and IV lymphoma in client owned dogs. Diagnosis of lymphoma must be confirmed by cytology or biopsy for the dog to be eligible for this study. Dogs will be randomized to receive the investigational veterinary product or a placebo treatment (tablets) to be administered with food twice weekly at least 72 hours apart for 8 weeks. After receiving treatment in-hospital on Day 0, the dog will be required to return to the study site on Days 7, 14, 28, 42, and 56 for follow up evaluation visits. Owners will be required to report and record abnormal daily observations and dosing using a phone app at home throughout the study.

Apply if...
  • Your dog has naïve or first relapse lymphoma
  • Your dog is over 1 year old and weighs more than 9kgs (~20lbs)
  • Your dog has a confirmed diagnosis of B or T cell lymphoma in stage II III or IV
  • Your dog has a ECOG performance status of less than or equal to 1
Compensation

Funding for the study includes:

  • Initial Study Screening

  • Scheduled Study Lab Work

  • Recheck visits and Exams

  • Managment of side effects

MALVERN, PA

RECRUITING

Anivive LifesciencesAnivive Lifesciences
Canine Diabetes

Canine Diabetes

Endocrinology
Observational

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

Apply if...
  • Your dog has been recently diagnosed with canine diabetes
  • Your dog has other endocrine related disease or is a non-spayed female
Compensation

Free Participation
Enrolled pets receive free:

  • Bloodwork
  • Urine Sample
  • Repeated Vet Checkups

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida
Complement Inhibition in Canine IMHA

Complement Inhibition in Canine IMHA

Investigational

Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and can be fatal. In the severe form of the disease complement activation causes red blood cells to be broken down in the bloodstream. At present no therapies for IMHA target this complement activation. We have confirmed that an FDA licensed formulation of C1-INH is safe for dogs and effectively inhibits canine complement mediated hemolysis. We hope this will translate into a beneficial effect in dogs with intravascular red cell breakdown due to IMHA.

Apply if...
  • Your dog has been diagnosed with IMHA
Compensation
Diagnostic Testing and follow up monitoring

ITHACA, NY

ENROLLING

CornellCornell
DCM in Dobermans

DCM in Dobermans

Cardiology
Investigational

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

Apply if...
  • Your dog has been diagnosed with dilated cardiomyopathy
  • Your dog has no other heart conditions
Compensation

Free Participation
Enrolled pets receive free:

  • Free participation
  • bloodwork
  • ECHO
  • ECG
  • Repeated vet checkups

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida
Determining the Transcriptome of Canine Soft Tissue Sarcoma

Determining the Transcriptome of Canine Soft Tissue Sarcoma

Oncology
Observational

Soft tissue sarcomas (STS) are tumors that arise from various skin and connective tissues under the skin, such as fat, muscle, cartilage, nerves, or small blood vessels. These tumors can occur from any site on the body and commonly regrow after tumor removal. While surgical removal and other therapies are available to treat these tumors, little is known as to why the occur in the first place. Dr. Andrew Miller and his lab are collecting samples of canine soft tissue sarcomas in order to determine their RNA molecules, otherwise known as transcriptomes. This information will one day lead to new treatments and preventives for these tumors.

Apply if...
  • Your dog needs surgery to remove an STS
Compensation
Cost of Histopathology

ITHACA, NY

ENROLLING

CornellCornell
Dietary Trial for Cats with IBD or GI Lymphoma

Dietary Trial for Cats with IBD or GI Lymphoma

Internal Medicine
Investigational

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

Apply if...
  • Any Cat with signs of chronic GI disease
Compensation
Hospital discount on study-related visits

ITHACA, NY

ENROLLING

CornellCornell
Canine Lymphoma

MALVERN, PA

RECRUITING

Anivive LifesciencesAnivive Lifesciences

Canine Lymphoma

Oncology
Investigational

Lymphoma is one of the most commonly encountered cancers in the dog. The incidence of canine lymphoma has steadily increased with approximately 84 per 10,000 dogs diagnosed each year. This randomized, double-masked, placebo-controlled, GCP pivotal field study is evaluating the effectiveness and safety of verdinexor for the treatment of naïve or first relapse stages II, III and IV lymphoma in client owned dogs. Diagnosis of lymphoma must be confirmed by cytology or biopsy for the dog to be eligible for this study. Dogs will be randomized to receive the investigational veterinary product or a placebo treatment (tablets) to be administered with food twice weekly at least 72 hours apart for 8 weeks. After receiving treatment in-hospital on Day 0, the dog will be required to return to the study site on Days 7, 14, 28, 42, and 56 for follow up evaluation visits. Owners will be required to report and record abnormal daily observations and dosing using a phone app at home throughout the study.

Apply if...
  • Your dog has naïve or first relapse lymphoma
  • Your dog is over 1 year old and weighs more than 9kgs (~20lbs)
  • Your dog has a confirmed diagnosis of B or T cell lymphoma in stage II III or IV
  • Your dog has a ECOG performance status of less than or equal to 1

Funding for the study includes:

  • Initial Study Screening

  • Scheduled Study Lab Work

  • Recheck visits and Exams

  • Managment of side effects

Canine Diabetes

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida

Canine Diabetes

Endocrinology
Observational

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

Apply if...
  • Your dog has been recently diagnosed with canine diabetes
  • Your dog has other endocrine related disease or is a non-spayed female

Free Participation
Enrolled pets receive free:

  • Bloodwork
  • Urine Sample
  • Repeated Vet Checkups

Complement Inhibition in Canine IMHA

ITHACA, NY

ENROLLING

CornellCornell

Complement Inhibition in Canine IMHA

Investigational

Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and can be fatal. In the severe form of the disease complement activation causes red blood cells to be broken down in the bloodstream. At present no therapies for IMHA target this complement activation. We have confirmed that an FDA licensed formulation of C1-INH is safe for dogs and effectively inhibits canine complement mediated hemolysis. We hope this will translate into a beneficial effect in dogs with intravascular red cell breakdown due to IMHA.

Apply if...
  • Your dog has been diagnosed with IMHA
Diagnostic Testing and follow up monitoring
DCM in Dobermans

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida

DCM in Dobermans

Cardiology
Investigational

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

Apply if...
  • Your dog has been diagnosed with dilated cardiomyopathy
  • Your dog has no other heart conditions

Free Participation
Enrolled pets receive free:

  • Free participation
  • bloodwork
  • ECHO
  • ECG
  • Repeated vet checkups

Determining the Transcriptome of Canine Soft Tissue Sarcoma

ITHACA, NY

ENROLLING

CornellCornell

Determining the Transcriptome of Canine Soft Tissue Sarcoma

Oncology
Observational

Soft tissue sarcomas (STS) are tumors that arise from various skin and connective tissues under the skin, such as fat, muscle, cartilage, nerves, or small blood vessels. These tumors can occur from any site on the body and commonly regrow after tumor removal. While surgical removal and other therapies are available to treat these tumors, little is known as to why the occur in the first place. Dr. Andrew Miller and his lab are collecting samples of canine soft tissue sarcomas in order to determine their RNA molecules, otherwise known as transcriptomes. This information will one day lead to new treatments and preventives for these tumors.

Apply if...
  • Your dog needs surgery to remove an STS
Cost of Histopathology
Dietary Trial for Cats with IBD or GI Lymphoma

ITHACA, NY

ENROLLING

CornellCornell

Dietary Trial for Cats with IBD or GI Lymphoma

Internal Medicine
Investigational

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

Apply if...
  • Any Cat with signs of chronic GI disease
Hospital discount on study-related visits

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Trials Faster.

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