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Dilated Cardiomyopathy

DCM in Dobermans

Has your Doberman been diagnosed with DCM? Help us find the cure.

Canine Diabetes

Canine Diabetes

Endocrinology
Observational

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

Apply if...
  • Your dog has been recently diagnosed with canine diabetes
  • Your dog has other endocrine related disease or is a non-spayed female
Compensation

Free Participation
Enrolled pets receive free:

  • Bloodwork
  • Urine Sample
  • Repeated Vet Checkups

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida
Complement Inhibition in Canine IMHA

Complement Inhibition in Canine IMHA

Investigational

Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and can be fatal. In the severe form of the disease complement activation causes red blood cells to be broken down in the bloodstream. At present no therapies for IMHA target this complement activation. We have confirmed that an FDA licensed formulation of C1-INH is safe for dogs and effectively inhibits canine complement mediated hemolysis. We hope this will translate into a beneficial effect in dogs with intravascular red cell breakdown due to IMHA.

Apply if...
  • Your dog has been diagnosed with IMHA
Compensation
Diagnostic Testing and follow up monitoring

ITHACA, NY

ENROLLING

CornellCornell
DCM in Dobermans

DCM in Dobermans

Cardiology
Investigational

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

Apply if...
  • Your dog has been diagnosed with dilated cardiomyopathy
  • Your dog has no other heart conditions
Compensation

Free Participation
Enrolled pets receive free:

  • Free participation
  • bloodwork
  • ECHO
  • ECG
  • Repeated vet checkups

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida
Determining the Transcriptome of Canine Soft Tissue Sarcoma

Determining the Transcriptome of Canine Soft Tissue Sarcoma

Oncology
Observational

Soft tissue sarcomas (STS) are tumors that arise from various skin and connective tissues under the skin, such as fat, muscle, cartilage, nerves, or small blood vessels. These tumors can occur from any site on the body and commonly regrow after tumor removal. While surgical removal and other therapies are available to treat these tumors, little is known as to why the occur in the first place. Dr. Andrew Miller and his lab are collecting samples of canine soft tissue sarcomas in order to determine their RNA molecules, otherwise known as transcriptomes. This information will one day lead to new treatments and preventives for these tumors.

Apply if...
  • Your dog needs surgery to remove an STS
Compensation
Cost of Histopathology

ITHACA, NY

ENROLLING

CornellCornell
Dietary Trial for Cats with IBD or GI Lymphoma

Dietary Trial for Cats with IBD or GI Lymphoma

Internal Medicine
Investigational

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

Apply if...
  • Any Cat with signs of chronic GI disease
Compensation
Hospital discount on study-related visits

ITHACA, NY

ENROLLING

CornellCornell
Drug Repurposing to Aid Treatment of Canine Lymphoma

Drug Repurposing to Aid Treatment of Canine Lymphoma

Oncology

Lymphoma is one of the most common cancers in dogs with few treatment options available. Traditional chemotherapeutic drugs have been used to extend quality of life, achieve clinical remissions, and slow cancer progression, but can be expensive.  Additional safe, low cost therapies are needed for canine patients. This study repurposes an antibiotic drug that has established data regarding its benefit and safety in dogs when used to treat certain infections. Furthermore, research has shown that this drug decreases the ability of the lymphoma cells to thrive in a laboratory setting. In the current study, dogs will be prospectively enrolled to receive either prednisone alone or prednisone in combination with the study drug. This study is available through the Cornell University College of Veterinary Medicine Oncology service and is sponsored by the Cornell University Animal Health Grants Program.

Apply if...
  • Your dog has been diagnosed with Large Cell Lymphoma
  • Your dog is able to receive twice daily oral medication
  • Your dog is under the age of 2
  • Your dog has not already received treatment for Canine Lymphoma
Compensation
  • Blood Tests

  • Urine Samples and Analysis

  • Radiographs and Abdominal Ultrasounds

ITHACA, NY

ENROLLING

CornellCornell
Canine Diabetes

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida

Canine Diabetes

Endocrinology
Observational

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

Apply if...
  • Your dog has been recently diagnosed with canine diabetes
  • Your dog has other endocrine related disease or is a non-spayed female

Free Participation
Enrolled pets receive free:

  • Bloodwork
  • Urine Sample
  • Repeated Vet Checkups

Complement Inhibition in Canine IMHA

ITHACA, NY

ENROLLING

CornellCornell

Complement Inhibition in Canine IMHA

Investigational

Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and can be fatal. In the severe form of the disease complement activation causes red blood cells to be broken down in the bloodstream. At present no therapies for IMHA target this complement activation. We have confirmed that an FDA licensed formulation of C1-INH is safe for dogs and effectively inhibits canine complement mediated hemolysis. We hope this will translate into a beneficial effect in dogs with intravascular red cell breakdown due to IMHA.

Apply if...
  • Your dog has been diagnosed with IMHA
Diagnostic Testing and follow up monitoring
DCM in Dobermans

GAINESVILLE, FL

ENROLLING

University of FloridaUniversity of Florida

DCM in Dobermans

Cardiology
Investigational

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

Apply if...
  • Your dog has been diagnosed with dilated cardiomyopathy
  • Your dog has no other heart conditions

Free Participation
Enrolled pets receive free:

  • Free participation
  • bloodwork
  • ECHO
  • ECG
  • Repeated vet checkups

Determining the Transcriptome of Canine Soft Tissue Sarcoma

ITHACA, NY

ENROLLING

CornellCornell

Determining the Transcriptome of Canine Soft Tissue Sarcoma

Oncology
Observational

Soft tissue sarcomas (STS) are tumors that arise from various skin and connective tissues under the skin, such as fat, muscle, cartilage, nerves, or small blood vessels. These tumors can occur from any site on the body and commonly regrow after tumor removal. While surgical removal and other therapies are available to treat these tumors, little is known as to why the occur in the first place. Dr. Andrew Miller and his lab are collecting samples of canine soft tissue sarcomas in order to determine their RNA molecules, otherwise known as transcriptomes. This information will one day lead to new treatments and preventives for these tumors.

Apply if...
  • Your dog needs surgery to remove an STS
Cost of Histopathology
Dietary Trial for Cats with IBD or GI Lymphoma

ITHACA, NY

ENROLLING

CornellCornell

Dietary Trial for Cats with IBD or GI Lymphoma

Internal Medicine
Investigational

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

Apply if...
  • Any Cat with signs of chronic GI disease
Hospital discount on study-related visits
Drug Repurposing to Aid Treatment of Canine Lymphoma

ITHACA, NY

ENROLLING

CornellCornell

Drug Repurposing to Aid Treatment of Canine Lymphoma

Oncology

Lymphoma is one of the most common cancers in dogs with few treatment options available. Traditional chemotherapeutic drugs have been used to extend quality of life, achieve clinical remissions, and slow cancer progression, but can be expensive.  Additional safe, low cost therapies are needed for canine patients. This study repurposes an antibiotic drug that has established data regarding its benefit and safety in dogs when used to treat certain infections. Furthermore, research has shown that this drug decreases the ability of the lymphoma cells to thrive in a laboratory setting. In the current study, dogs will be prospectively enrolled to receive either prednisone alone or prednisone in combination with the study drug. This study is available through the Cornell University College of Veterinary Medicine Oncology service and is sponsored by the Cornell University Animal Health Grants Program.

Apply if...
  • Your dog has been diagnosed with Large Cell Lymphoma
  • Your dog is able to receive twice daily oral medication
  • Your dog is under the age of 2
  • Your dog has not already received treatment for Canine Lymphoma
  • Blood Tests

  • Urine Samples and Analysis

  • Radiographs and Abdominal Ultrasounds

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