Anivive Lifesciences

Schedule

Team

Enrolled pets receive:

Compensation

Endocrinology

Observational

A new partnership between Anivive Lifesciences and Basepaws has formed to study the genetics of feline diabetes. Cats meeting the study criteria are eligible to receive complimentary genetic testing. Your participation in this study is an opportunity to support scientific exploration of the genes thought to be involved with diabetes. This information will help researchers develop new diagnostic tests, suggest possible preventative measures and explore new treatments for this common feline disease.

Feline Diabetes

Anivive | Basepaws Partnership<br>Join the movement to expand our understanding of the genetics of feline diabetes and help advance cat health.

Department of Small Animal Clinical Sciences, University of Florida

University of Florida

Treatment

Enrolled pets receive free:

Cardiology

Investigational

Dilated Cardiomyopathy (DCM) is a disease of heart muscle that results in a decreased ability of the heart to pump blood. The prognosis for DCM is often poor, with a less than 50% survival rate one year after clinical signs develop, unless a reversible underlying cause is identified. There is no available cure for Dilated Cardiomyopathy, current techniques focus on extending survival time as long as possible. However the focus of this clinical trial is to evaluate a potential curative treatment for cardiomyopathy in the Doberman Pinscher.

DCM in Dobermans

Has your Doberman been diagnosed with DCM? Help us find the cure.

Cornell University Hospital for Animals (CUHA)

Cornell

Infectious

Dr. Gary Whittaker, of the Whittaker Lab, in the Department of Microbiology and Immunology at the Cornell University College of Veterinary Medicine, is continuing the regional study of the feline infectious peritonitis (FIP) virus and how it infects cats. The aim is to reach a better understanding of this virus in order to formulate a successful method of treatment and to work towards a future diagnostic test.

Studying the Genetics of Feline Infectious Peritonitis (FIP)

The aim is to reach a better understanding of this virus in order to formulate a successful method of treatment and to work towards a future diagnostic test.

Oncology

Hemangiosarcoma is the most common splenic cancer diagnosed in dogs. The standard of care treatment is splenectomy (surgery) followed by doxorubicin chemotherapy, but long-term survival remains poor. We are continuously looking for additional well-tolerated treatments that may prolong survival for dogs with this disease.

Investigating a New Treatment for Hemangiosarcoma

This study will help us to determine if dogs that receive temozolomide and doxorubicin do better than with doxorubicin alone.

View Studies

For Pet Owners

For Veterinarians

Diabetes mellitus is an important health problem in both dogs and people. Type 1 diabetes (T1D) in people is caused by an attack of the body’s own immune system on cells in the pancreas. Diabetes in dogs is thought to be similar in some ways to T1D in people, but there is still much more to learn about the causes of diabetes in dogs as well as better ways to prevent and treat the disease. The purpose of this study is to learn more about metabolism and immune function in diabetic dogs.

Canine Diabetes

If your dog has diabetes enroll them in our new research study, to help understand the causes of canine diabetes

Immune-mediated hemolytic anemia (IMHA) is a common disease that affects all breeds of dogs and can be fatal. In the severe form of the disease complement activation causes red blood cells to be broken down in the bloodstream.

At present no therapies for IMHA target this complement activation. We have confirmed that an FDA licensed formulation of C1-INH is safe for dogs and effectively inhibits canine complement mediated hemolysis. We hope this will translate into a beneficial effect in dogs with intravascular red cell breakdown due to IMHA.

Complement Inhibition in Canine IMHA

We aim to assess the efficacy of C1-INH for management of intravascular IMHA. This is a double-blinded, randomized controlled trial which means patients will be randomized to receive either C1-INH or a saline placebo infusion three times.

Soft tissue sarcomas (STS) are tumors that arise from various skin and connective tissues under the skin, such as fat, muscle, cartilage, nerves, or small blood vessels. These tumors can occur from any site on the body and commonly regrow after tumor removal. While surgical removal and other therapies are available to treat these tumors, little is known as to why the occur in the first place. Dr. Andrew Miller and his lab are collecting samples of canine soft tissue sarcomas in order to determine their RNA molecules, otherwise known as transcriptomes. This information will one day lead to new treatments and preventives for these tumors.

Determining the Transcriptome of Canine Soft Tissue Sarcoma

Dr. Andrew Miller and his lab are collecting samples of canine soft tissue sarcomas to help develop new treatments and preventives for these tumors.

Internal Medicine

The clinical signs in some cats with chronic enteropathy (chronic vomiting and/or diarrhea) can be reversed with dietary management using a specially formulated diet. It is not clear why some cats respond to diet, or what the optimal composition of the diet for cats with chronic enteropathy should be. We want to know if diets containing proteins that are selected to minimize immune responses and fortified in Vitamin B12 and natural anti-inflammatory agents (prebiotics and curcumin) are better than conventional diets for cats with chronic enteropathy.

Dietary Trial for Cats with IBD or GI Lymphoma

The diagnosis of chronic enteropathy can include cats with chronic vomiting and/or diarrhea, cats with biopsy-diagnosed IBD (inflammatory bowel disease) and cats with small cell GI lymphoma.

Lymphoma is one of the most common cancers in dogs with few treatment options available. Traditional chemotherapeutic drugs have been used to extend quality of life, achieve clinical remissions, and slow cancer progression, but can be expensive.  Additional safe, low cost therapies are needed for canine patients. This study repurposes an antibiotic drug that has established data regarding its benefit and safety in dogs when used to treat certain infections. Furthermore, research has shown that this drug decreases the ability of the lymphoma cells to thrive in a laboratory setting. In the current study, dogs will be prospectively enrolled to receive either prednisone alone or prednisone in combination with the study drug. This study is available through the Cornell University College of Veterinary Medicine Oncology service and is sponsored by the Cornell University Animal Health Grants Program.

Drug Repurposing to Aid Treatment of Canine Lymphoma

The purpose of this study is to determine if a repurposed antibiotic drug can improve the outcome for dogs with large cell lymphoma receiving concurrent prednisone compared to dogs receiving prednisone alone. Additionally, we will obtain data to identify

Diabetic Ketoacidosis (DKA) is a serious complication of diabetes that occurs when the body produces high levels of ketones which causes the blood to be more acid than is normal. This can be triggered by infection or other illness. It can be life threatening and treatment requires hospitalization with IV (intravenous) fluids and insulin therapy.

The usual treatment of DKA is to give regular insulin intravenously based on a sliding scale relative to their blood glucose level in addition to other standard supportive care therapies. We would like to investigate if a different (novel) scale for insulin therapy is more effective. This novel administration protocol more closely mimics the insulin regimen in human medicine. Our goal is to find a protocol that results in faster resolution of the DKA state which would result in shorter hospitalization times and lower costs to owners.

Investigating a New Treatment Plan for DKA

Investigating a novel insulin CRI dosing to treat DKA

Immune-Mediated Hemolytic Anemia (IMHA) and Immune-Mediated Thrombocytopenia (ITP) are common immune diseases in dogs. Studies of other diseases suggest that the bacteria that live in the gastrointestinal tract (the microbiome) may help cause autoimmune disorders.

Investigating the Microbiome of Dogs with IMHA and ITP

This study intends to determine if there is a link between immune-mediated hemolytic anemia and the microbiome. Specifically, we are interested to find whether dogs with IMHA have similar microbiomes and if changes in the microbiome can predict recovery.

Affenpinscher

Afghan Hound

Airedale Terrier

Akita

Alaskan Malamute

Alaskan Husky

American English Coonhound

American Eskimo Dog (Miniature)

American Eskimo Dog (Standard)

American Eskimo Dog (Toy)

American Foxhound

American Hairless Terrier

American Staffordshire Terrier

American Water Spaniel

Anatolian Shepherd Dog

Australian Cattle Dog

Australian Shepherd

Australian Terrier

Azawakh

Basenji

Basset Hound

Beagle

Bearded Collie

Beauceron

Bedlington Terrier

Belgian Malinois

Belgian Sheepdog

Belgian Tervuren

Bergamasco

Berger Picard

Bernese Mountain Dog

Bichon Frise

Black and Tan Coonhound

Black Russian Terrier

Bloodhound

Bluetick Coonhound

Boerboel

Border Collie

Border Terrier

Borzoi

Boston Terrier

Bouvier des Flandres

Boxer

Boykin Spaniel

Briard

Brittany

Brussels Griffon

Bull Terrier

Bulldog

Bullmastiff

Cairn Terrier

Canaan Dog

Carp Terrier

Cane Corso

Cardigan Welsh Corgi

Cavalier King Charles Spaniel

Cesky Terrier

Chesapeake Bay Retriever

Chihuahua

Chinese Crested Dog

Chinese Shar Pei

Chinook

Chow Chow

Cirneco dell'Etna

Clumber Spaniel

Cocker Spaniel

Collie

Coton de Tulear

Curly-Coated Retriever

Dachshunds

Dalmatian

Dandie Dinmont Terrier

Doberman Pinscher

Dogue de Bordeaux

Dominican Labrador Retriever

English Cocker Spaniel

English Foxhound

English Setter

English Springer Spaniel

English Toy Spaniel

Entlebucher Mountain Dog

Eurohound

Field Spaniel

Finnish Lapphund

Finnish Spitz

Flat-Coated Retriever

French Bulldog

German Pinscher

German Shepherd Dog

German Shorthaired Pointer

German Wirehaired Pointer

Giant Schnauzer

Glen of Imaal Terrier

Golden Retriever

Gordon Setter

Great Dane

Great Pyrenees

Greater Swiss Mountain Dog

Greyhound

Harrier

Akhal Teke

Altai

American Cream Draft

American Saddlebred

Andalusian

Andravida

Appaloosa

Arabian

Australian Stock Horse

Barb

Bashkir Curly

Basotho Pony

Belgian

Black Forest

Breton

Camargue

Campolina

Caspian

Cheju

Chincoteague Pony

Cleveland Bay

Clydesdale

Connemara Pony

Criollo

Crioulo

Dales Pony

Dartmoor Pony

Dutch Warmblood

Eriskay Pony

Exmoor Pony

Falabella

Fell Pony

Finnhorse

French Saddlebred

French Trotter

Friesian

Galician Pony

Gotland

Haflinger

Hanoverian

Hequ

Highland Pony

Hokkaido

Holsteiner

Hucul

Hungarian Warmblood

Icelandic

Featured

Feline Diabetes

DCM in Dobermans

Studying the Genetics of Feline Infectious Peritonitis (FIP)

Investigating a New Treatment for Hemangiosarcoma